Article Sidebar

Download
PDF
Statistic
Read Counter : 17 Download : 31

Downloads

Download data is not yet available.

Main Article Content

Abstract

Postprandial hyperglycemia is a key metabolic disturbance associated with the progression to Type 2 Diabetes Mellitus, highlighting the need for effective preventive strategies. Psidium guajava leaves contain bioactive compounds, including flavonoids, tannins, and polyphenols, that have been investigated for their antihyperglycemic potential. This systematic review, conducted in accordance with PRISMA guidelines, synthesized evidence from 12 included studies comprising two in vitro studies, six in vivo studies, three clinical studies, and one mixed review–experimental study. The findings suggest that guava leaf preparations may attenuate postprandial glycemic responses through complementary mechanisms, including inhibition of carbohydrate-digesting enzymes, enhancement of cellular glucose uptake, improvement of insulin sensitivity, and reduction of oxidative stress. Clinical studies reported reductions in postprandial glucose responses, while experimental investigations provided supporting mechanistic evidence. However, methodological heterogeneity, limited clinical evidence, and uncertainties in study quality restrict the strength of these findings. Overall, Psidium guajava leaf preparations demonstrate potential as a complementary approach to postprandial glycemic management, although further well-designed clinical trials are required to establish their efficacy, optimal dosage, and long-term safety.

Keywords

Antioxidant activity Bioactive compounds Glycemic control Psidium guajava leaves

Article Details

License

Copyright (c) 2026 Fitrina Syawalani Idwar, Lucky Nadia, Muhammad Rasyid Ridha, Giska Putri

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite
Idwar, F. S., Nadia, L., Ridha, M. R., & Putri, G. (2026). Bioactive Compounds of Psidium guajava Leaves and Their Role in Attenuating Postprandial Glucose Excursions: A Systematic Review. Grimsa Journal of Science Engineering and Technology, 4(2), 76–85. https://doi.org/10.61975/gjset.v4i2.114
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Ceriello A, Davidson J, Hanefeld M, Leiter L, Monnier L, Owens D, et al. Postprandial Hyperglycaemia and Cardiovascular Complications of Diabetes: An Update. Nutrition, Metabolism and Cardiovascular Diseases 2006;16:453–6. https://doi.org/10.1016/j.numecd.2006.05.006.
  2. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels, Belgium: International Diabetes Federation; 2021.
  3. Gafur F, Assa Y, Tiho M. Analyzing The Correlation of Uric Acid and Fasting Blood Sugar in Type 2 Diabetes Patients: A Study from ODSK Hospital, North Sulawesi, Indonesia. Grimsa Journal of Science Engineering and Technology 2025;3:63–72. https://doi.org/10.61975/gjset.v3i2.66.
  4. Maulana A, Faisal FR, Noviandy TR, Rizkia T, Idroes GM, Tallei TE, et al. Machine Learning Approach for Diabetes Detection Using Fine-Tuned XGBoost Algorithm. Infolitika Journal of Data Science 2023;1:1–7. https://doi.org/10.60084/ijds.v1i1.72.
  5. Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C. Alpha-Glucosidase Inhibitors for Type 2 Diabetes Mellitus. Cochrane Database of Systematic Reviews 2005;2009:CD003639. https://doi.org/10.1002/14651858.CD003639.pub2.
  6. Gutiérrez RMP, Mitchell S, Solis RV. Psidium Guajava: A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Journal of Ethnopharmacology 2008;117:1–27. https://doi.org/10.1016/j.jep.2008.01.025.
  7. Chen H-Y, Yen G-C. Antioxidant Activity and Free Radical-Scavenging Capacity of Extracts from Guava (Psidium Guajava L.) Leaves. Food Chemistry 2007;101:686–94. https://doi.org/10.1016/j.foodchem.2006.02.047.
  8. Essa HA, ElMosbah DE, Fahmy HA. Combined Polyphenols in Psidium Guajava-Citrus Limon Leaf Extract Attenuate Fructose-Induced Cardiac Injury by Modulating Metabolic and Oxidative Stress Pathways in Rats. PLOS One 2026;21:e0339641. https://doi.org/10.1371/journal.pone.0339641.
  9. Deguchi Y, Miyazaki K. Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Guava Leaf Extract. Nutrition & Metabolism 2010;7:9. https://doi.org/10.1186/1743-7075-7-9.
  10. Butt E, Altemimi AB, Younas A, Butt MS, Jalal M, Bhatty M, et al. Guava (Psidium Guajava): A Brief Overview of Its Therapeutic and Health Potential. Food Chemistry: X 2025;31:103027. https://doi.org/10.1016/j.fochx.2025.103027.
  11. Luo Y, Peng B, Wei W, Tian X, Wu Z. Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves. Molecules 2019;24:1343. https://doi.org/10.3390/molecules24071343.
  12. Wang B, Liu H-C, Hong J-R, Li H-G, Huang C-Y. Effect of Psidium Guajava Leaf Extract on Alpha-Glucosidase Activity in Small Intestine of Diabetic Mouse. Sichuan Da Xue Xue Bao Yi Xue Ban 2007;38:298–301.
  13. Lee WC, Mahmud R, Pillai S, Perumal S, Ismail S. Antioxidant Activities of Essential Oil of Psidium Guajava L. Leaves. APCBEE Procedia 2012;2:86–91. https://doi.org/10.1016/j.apcbee.2012.06.016.
  14. Shen S-C, Cheng F-C, Wu N-J. Effect of Guava ( Psidium Guajava Linn.) Leaf Soluble Solids on Glucose Metabolism in Type 2 Diabetic Rats. Phytotherapy Research 2008;22:1458–64. https://doi.org/10.1002/ptr.2476.
  15. Huang C-S, Yin M-C, Chiu L-C. Antihyperglycemic and Antioxidative Potential of Psidium Guajava Fruit in Streptozotocin-Induced Diabetic Rats. Food and Chemical Toxicology 2011;49:2189–95. https://doi.org/10.1016/j.fct.2011.05.032.
  16. Rai PK, Jaiswal D, Mehta S, Watal G. Anti-Hyperglycaemic Potential of Psidium Guajava Raw Fruit Peel. Indian Journal of Medical Research 2009;129:561–5.
  17. Ali H, Houghton PJ, Soumyanath A. α-Amylase Inhibitory Activity of Some Malaysian Plants Used to Treat Diabetes; with Particular Reference to Phyllanthus Amarus. Journal of Ethnopharmacology 2006;107:449–55. https://doi.org/10.1016/j.jep.2006.04.004.
  18. Rahman MM, Ahmad SH, Mohamed MTM, Ab Rahman MZ. Antimicrobial Compounds from Leaf Extracts of Jatropha Curcas , Psidium Guajava , and Andrographis Paniculata. The Scientific World Journal 2014;2014:1–8. https://doi.org/10.1155/2014/635240.
  19. Rajput R, Kumar K. Protective Effect of Ethanolic Extract of Guava Leaves (Psidium Guajava L.) in Alloxan-Induced Diabetic Mice. Materials Today: Proceedings 2021;47:437–9. https://doi.org/10.1016/j.matpr.2021.04.617.